設為主頁 加入收藏 English
华东15选5选号方法
 
 
 
 新聞動態
 行業動態
 展會信息
 
 

Nanobrook Omni測量應用案例-97

發布時間:2019-04-18  點擊次數:46  新聞來源:
 

文獻名:Biodistribution, excretion, and toxicity of polyethyleneimine modified NaYF4:Yb,Er upconversion nanoparticles in mice via different administration routes

 

作者: Jie Yu,ab  Wenyan Yin,b  Tao Peng,b  Ya-nan Chang,b  Yan Zu,b  Juan Li,b  Xiao He,b  Xiaoyan Ma,a  Zhanjun Gub  and  Yuliang Zhaobc   

 a Key Laboratory of Polymer Science and Technology, School of Science, Northwestern Polytechnical University, Xi'an, China

b Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, China

c CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, China

 

摘要:Upconversion nanoparticles (UCNPs) have drawn much attention in biomedicine, and the clinical translation of UCNPs is closely related to their toxicity and metabolism in vivo. In this study, we chose polyethyleneimine modified NaYF4:Yb,Er upconversion nanoparticles (abbreviated as [email protected]) to systematically study the biodistribution in mice using intravenous (i.v.), intraperitoneal (i.p.), and intragastric (i.g.) administration. The i.p. injected [email protected] exhibited obvious accumulation in the spleen within 30 days. Comparably, [email protected] via i.g. administration exhibited an accumulation that decreased with time in various body tissues and were found mainly in the ileum and cecum but were rather low in concentration in the other examined organs. For the i.v. injected group, the UCNPs exhibited an obvious clearance from the body within 30 days and the accumulation in the spleen gradually decreased. Furthermore, 64Cu labeled [email protected] were i.v. injected for real-time photon emission computed tomography (PET) imaging to further confirm the biodistribution in mice. Afterward, the excretion routes of the [email protected] were evaluated. For i.p. injected groups, the UCNPs were slowly and partly excreted via feces and urine for 30 days, and a large number of the UCNPs were steadily excreted via feces for the i.v. group, suggesting that the UCNPs via i.v. injection can be potentially used for imaging and therapy studies in vivo. However, for the i.g. administrated group, most of the UCNPs were excreted through feces within 48 h. Hematology, body weight, and biochemical analysis were used to further quantify the potential toxicity of the UCNPs, and results indicated that there was no over toxicity of the UCNPs in mice at the tested period. This work suggests that the clearance and excretion capabilities of [email protected] are particularly dependent on their administration routes.

 

 
 
北京市海淀區北三環西路48號北京科技會展中心1A6B 電話:010-5162 7740 400-718-7758 傳真:010-5162 7742
美國布魯克海文儀器公司 版權所有  管理登陸 ICP備案號:华东15选5选号方法 技術支持:化工儀器網